Hypofractionated Postmastectomy Radiation Therapy

Hypofractionated radiation therapy for glioblastoma

Mounting Evidence for Postmastectomy Locoregional Radiation Therapy

Déjà vu All Over Again? Although a substantial number of women will suffer and die from breast cancer during the upcoming years, we clearly have made stepwise progress in treating patients with this cancer over the last 3 decades. Each of these steps of progress has led to what are glibly designated “paradigm shifts.” Perhaps the most hotly debated of these paradigms is the local vs systemic na...

Consensus Statement on postmastectomy radiation therapy.

1. Reduction in the recurrence rate of clinically detectable local-regional disease by PMRT is evident. 2. The most recent randomized controlled trials, including two well-designed trials using modern radiation techniques, have shown a moderate and statistically significant improvement in survival. 3. Consultation with a radiation oncologist should occur in postmastectomy node-positive patients...

Mounting evidence for postmastectomy locoregional radiation therapy.

Postmastectomy locoregional radiation therapy markedly reduces the risk of locoregional recurrence. Several randomized trials, including two recently updated studies with 10- to 15-year follow-up, demonstrate an improvement in overall survival with radiation therapy. This improvement is seen in patients with one to three positive axillary lymph nodes, as well those with four positive nodes. The...

Postmastectomy radiation therapy in locally advanced breast cancer.

Despite wide efforts for early detection of breast cancer using screening mammography, locally advanced breast carcinomas account for a remarkable proportion of all breast carcinomas, particularly in developing countries. Locally advanced breast cancer may have widely different clinical and biological features. Radiotherapy plays an important role in the management of locally advanced breast ca...